Exploring the Antihyperlipidemic Properties of Piper nigrum
S.M. Fahim Hasan *
Department of Physiology, Anwer Khan Modern Medical College, Dhanmondi, Dhaka, Bangladesh.
Ikram Wahid Toha
Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh.
Md. Effadul Islam Econ
Department of Pharmacy, Southern University Bangladesh, Chittagong, Bangladesh.
Md. Nayeem Uddin
Department of Pharmacy, Southern University Bangladesh, Chittagong, Bangladesh.
Faisal Ahmed Shakil
Department of Pharmacy, University of Asia Pacific, 74/A Green Road, Dhaka, Bangladesh.
Nur Nobe
Department of Health Care Management, Saint Francis College, 179 Livingston St, Brooklyn, NY 11201, USA.
Sadia Tasnim
Department of Chemistry and Chemical Engineering, University of New Haven, West Haven, CT, USA.
*Author to whom correspondence should be addressed.
Abstract
Humans have used herbal medicine to address medical conditions since the inception of civilization. This study seeks to assess the effectiveness of Piper nigrum as an anti-hyperlipidemic drug and its influence on lipid profiles. We utilized the model to evaluate the effectiveness of the plant antihyperlipidemic activity. SGPT and SGOT levels were statistically significantly reduced (p < 0.05) in groups 6 and 5, respectively, at doses of 900 mg/kg and
600 mg/kg. No groups demonstrated statistically significant results in the renal function test. Despite a slight reduction in total cholesterol, HDL, LDL, and overall cholesterol, no group exhibited statistically significant outcomes. However, the elevated dosage of 900 mg/kg showed the most significant reduction in these metrics. The ethanolic extract of this plant demonstrates significant antihyperlipidemic effects, and further research may aid in the advancement of alternative medical uses.
Keywords: Piper nigrum, herbal medicine, antihyperlipidemic, creatinine, ethanol, SGOT